Table 3 Clinical evidences using non-selective NSAIDs in patients experiencing seizures
From: Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Reference | NSAID | Use | Study subjects | Effects |
|---|---|---|---|---|
van Stuijvenberg et al. [159] | Ibuprofen | Independent | Randomized, double-blind, placebo-controlled study in 230 children with febrile seizures (111 on ibuprofen and 119 on placebo) | Failed to reduce number of seizure recurrences in children at increased risk |
Udani et al. [160] | Aspirin | Not reported | 9 children with Sturge-Weber syndrome (6 with long-term continuous aspirin therapy and 3 with intermittent use of aspirin) | Seizure freedom for at least one year in 8 of 9 children |
Bay et al. [161] | Aspirin | In adjunction to AED therapy | Internet-based survey in 34 subjects with Sturge-Weber syndrome receiving aspirin | Seizure reduction in 21 of 34 patients |
Lance et al. [162] | Aspirin | In adjunction to AED therapy | 58 subjects with Sturge-Weber syndrome receiving aspirin | Seizure control in 91% of the patients |
Godfred et al. [163] | Aspirin | Independent | 46 subjects with focal epilepsy (23 receiving aspirin and 23 not receiving aspirin) | Fewer seizures in patients on aspirin therapy than patients not receiving it |