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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)

Fig. 4

miR-21a-5p is the candidate miR for EAE in females and males. a Joined volcano plots of DEmiRs; female DEmiRs = 29, male DEmiRs = 3. Vertical dotted lines represent log10(q = 0.1) as a cutoff threshold for significance. b Principal component analysis shows minimal separation of EAE and CFA animals by all miR sequencing data. Top two components are plotted. c Heatmaps of all DEmiRs in EAE. Values are Reads / Totals Reads normalized to the average of the CFA condition. d qPCR validation of miR-21a-5p in female and male DRGs. e qPCR validation of miR-122-5p in female and male DRGs. *p <  0.05, two-way ANOVAs with Sidak’s multiple comparison test. Bars indicate geometric mean with 95% confidence interval. DEmiR = differentially expressed miRs

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