Table 3 Significant changes of CSF immune cell subsets (absolute numbers and percentage distributions) and CSF cytokine concentrations are shown comparing neuro-inflammatory diseases with non-inflammatory neurological diseases (NIND)
Disease | Elevated CSF immune cell subtypes (absolute numbers) | Elevated CSF immune cell subsets (percentage) | Elevated CSF cytokine concentration |
|---|---|---|---|
CIS/RRMS | CD4 T cells ↑** CD8 T cells ↑*** B cells ↑*** Plasmablasts ↑*** NK cells ↑* | B cells ↑*** Plasmablasts ↑*** | CCL22 ↑*, CXCL13 ↑*** |
SPMS | |||
Lues | CD4 T cells ↑* CD8 T cells ↑* B cells ↑** | B cells ↑** | CXCL11 ↑*, CXCL13 ↑* |
LNB | CD4 T cells ↑** CD8 T cells ↑** B cells ↑*** | CD4 T cells ↓* B cells ↑*** | CCL3 ↑*, CCL7 ↑*, CCL8 ↑*, CXCL11 ↑*, CXCL13 ↑**, CXCL9 ↑**, IL2 ↑* |
Bacterial meningitis | CD4 T cells ↑** CD8 T cells ↑** B cells ↑** NK cells ↑** | CD4 T cells ↓* B cells ↑* | CCL1 ↑**, CCL11 ↑*, CCL13 ↑**, CCL19 ↑*, CCL20 ↑**, CCL23 ↑*, CCL25 ↑**, CCL3 ↑**, CCL7 ↑**, CCL8 ↑**, CXCL1 ↑**, CXCL11 ↑*, CXCL13 ↑**, CXCL2 ↑**, CXCL6 ↑**, CXCL8 ↑**, CXCL9 ↑**, IFNy ↑**, IL10 ↑**, IL16 ↑**, IL2 ↑**, IL6 ↑*, TNFα ↑** |
Viral meningitis | CD4 T cells ↑** CD8 T cells ↑** B cells ↑** NK cells ↑** | B cells ↑* NK cells ↑* | CCL1 ↑*, CCL19 ↑*, CCL20 ↑*, CCL22 ↑**, CCL3 ↑*, CCL7 ↑*, CCL8 ↑*, CX3CL1 ↑*, CXCL11 ↑**, CXCL12 ↑*, CXCL13 ↑**, CXCL2 ↑*, CXCL6 ↑*, CXCL9 ↑**, IFNy ↑*, IL16 ↑* |