Fig. 2
From: Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
EphA4 blocking peptides provide neuroprotection and reduce the pro-inflammatory response following 4 days CCI injury. a Quantified lesion volume at 4 days post-CCI injury in mice implanted with vehicle control, VTA-EEKK control, VTM-EEKK, and KYL peptides. *p < 0.05 compared to vehicle. b BBB disruption as measured by Evans blue absorbance (610 nm). Whole cortex EB absorbance is compared between and within the ipsilateral or contralateral hemisphere between vehicle, VTM-EEKK, and KYL-treated mice. *p < 0.05, **p < 0.01 compared to contralateral. c–f Representative images of Nissl-stained ipsilateral cortex at 4 days post-CCI injury in mice infused with vehicle, VTA-EEKK, VTM-EEKK, and KYL. g–j Quantified mRNA expression of pro-inflammatory Il6 and pro-resolving Arg1, Tie2, and Angpt2 respectively in the ipsilateral cortex relative to vehicle-infused sham injury vs vehicle 4 days post-CCI and after KYL and VTM-EEKK treatment. k–n Quantified mRNA expression in the whole blood of Il6, Ccr2, Mcp-1, and Il12 respectively from vehicle sham vs CCI-injured vehicle, KYL, VTM-EEKKK-infused mice. *p < 0.05, **p < 0.01, ***p < 0.001. n = 6 per group. Scale bar = 1 mm. Ctx, cortex; CC, corpus callosum; Hippo, hippocampus. n = 5–8 per group