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Table 2 Levels of human CD8regs and Bregs in PD patients and healthy controls

From: Regulatory impairment in untreated Parkinson’s disease is not restricted to Tregs: other regulatory populations are also involved

Cell subset

Control¢

PD¢

P value

CD8+

 

16.69 ± 8.60

14.55 ± 8.05

0.209

CD8+IL-10+

3.84 ± 2.47

2.47 ± 1.91

0.006*

CD8regs

(CD8+CD28-FOXP3)

13.21 ± 5.13

14.41 ± 5.41

0.522

Cytolytic CD8regs

(CD8+CD56+CD161-)

12.70 ± 7.03

13.08 ± 9.23

0.663

Functional CD8regs

(CD8+CD45RO+CCR7+IL-10+)

0.38 ± 0.31

0.23 ± 0.17

0.049*

CD19+

 

17.34 ± 6.65

17.35 ± 6.61

0.930

CD19+IL-10+

3.22 ± 1.58

3.173 ± 1.76

0.690

Plasmatic cells IL-10+

(CD19-CD138+IL-10+)

32.83 ± 14.04

26.13 ± 18.99

0.219

Functional Bregs

(CD19+CD38hiCD24hiIL-10+)

3.82 ± 2.16

2.64 ± 1.88

0.049*

Bregs

(CD19+CD5+CD1d+FOXP3+IL-10+)

1.49 ± 1.13

1.29 ± 0.91

0.555

  1. ¢Values are expressed as mean ± SD
  2. *P < 0.05 is considered as significant