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Table 2 Levels of human CD8regs and Bregs in PD patients and healthy controls

From: Regulatory impairment in untreated Parkinson’s disease is not restricted to Tregs: other regulatory populations are also involved

Cell subsetControl¢PD¢P value
CD8+ 16.69 ± 8.6014.55 ± 8.050.209
CD8+IL-10+3.84 ± 2.472.47 ± 1.910.006*
CD8regs
(CD8+CD28-FOXP3)
13.21 ± 5.1314.41 ± 5.410.522
Cytolytic CD8regs
(CD8+CD56+CD161-)
12.70 ± 7.0313.08 ± 9.230.663
Functional CD8regs
(CD8+CD45RO+CCR7+IL-10+)
0.38 ± 0.310.23 ± 0.170.049*
CD19+ 17.34 ± 6.6517.35 ± 6.610.930
CD19+IL-10+3.22 ± 1.583.173 ± 1.760.690
Plasmatic cells IL-10+
(CD19-CD138+IL-10+)
32.83 ± 14.0426.13 ± 18.990.219
Functional Bregs
(CD19+CD38hiCD24hiIL-10+)
3.82 ± 2.162.64 ± 1.880.049*
Bregs
(CD19+CD5+CD1d+FOXP3+IL-10+)
1.49 ± 1.131.29 ± 0.910.555
  1. ¢Values are expressed as mean ± SD
  2. *P < 0.05 is considered as significant