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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

Fig. 4

In vivo multimodal imaging of fDTH-EAE rat brain at acute (day 14) and chronic (day 90) phases of disease development with quantitative data. a Representative coronal MRI, 18F-FOL, and 11C-PBR28 PET/CT images and corresponding time-activity curves. White arrows denote inflammatory lesions. All PET images are displayed using the same color scale. Tracer uptake in the lesion is significantly higher than that in the contralateral site. ***P < 0.001. b Quantitative PET data presented as SUV ratios reveal significant differences between tracers in the chronic phase, but not in the acute phase. *P < 0.05. c Comparison of in vivo and ex vivo PET data. SUV ratio = SUVmax(lesion)/SUVmean(contralateral). R2 is Spearman’s correlation coefficient. Error bars denote standard deviation

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