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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

Fig. 1

Morphology of cerebral organoids during LACV infection. Representative brightfield images of a mock, b 3 dpi LACV, and c 6 dpi LACV COs. d-f Enlargements of boxed areas in a-c are shown. White arrows in d and e indicate areas of structural complexity that appear diminished by 6 dpi (f). Scale bar in c corresponds to a-f. g Representative immunofluorescence scanned image of a whole-mount, mock-infected cerebral organoid labeled with doublecortin (DCX, red) and Hoechst (blue) to label committed neurons and nuclei respectively. Areas in white boxes are analogous to those highlighted in a–f and are similar to areas focused on in subsequent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094