Table 1 List of significantly enriched Gene Ontology categories in (A) n-6 PUFA adequate and (B) n-6 PUFA deprived at day 1 LPS-administered mice compared to non-surgery mice
GO term | BY-corrected p value | No. of genes driving enrichment | GO term | BY-corrected p value | No. of genes driving enrichment |
|---|---|---|---|---|---|
A. Significantly enriched GO categories in n-6 PUFA adequate at baseline (non-surgery) vs day 1 LPS-administered mice | |||||
 Immune response | 1.18E−06 | 11 | Regulation of immune response | 0.05 | 5 |
 Innate immune response | 1.18E−06 | 9 | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.05 | 3 |
 Immune system process | 2.12E−05 | 12 | Immunoglobulin-mediated immune response | 0.05 | 3 |
 Cellular response to type I interferon | 1.90E−04 | 3 | Negative regulation of neuron projection development | 0.05 | 3 |
 Type I interferon signaling pathway | 1.90E−04 | 3 | B cell-mediated immunity | 0.05 | 3 |
 Defense response | 3.52E−04 | 9 | Regulation of adaptive immune response | 0.06 | 3 |
 Response to type I interferon | 3.75E−04 | 3 | Regulation of response to stimulus | 0.06 | 10 |
 Antigen processing and presentation of peptide antigen | 7.9E−04 | 4 | Defense response to virus | 0.06 | 3 |
 Immune effector process | 1.84E−03 | 6 | Extracellular space | 0.06 | 7 |
 Response to stress | 1.84E−03 | 12 | Viral process | 0.06 | 4 |
 Glycoprotein binding | 2.67E−03 | 4 | Multi-organism cellular process | 0.06 | 4 |
 Neuron projection regeneration | 2.67E−03 | 3 | Negative regulation of cell projection organization | 0.07 | 3 |
 Response to interferon-beta | 4.35E−03 | 3 | Regulation of immune effector process | 0.07 | 4 |
 Antigen processing and presentation | 5.28E−03 | 4 | Regulation of leukocyte mediated immunity | 0.08 | 3 |
 Response to external biotic stimulus | 5.46E−03 | 7 | Extracellular matrix organization | 0.08 | 3 |
 Response to other organism | 5.46E−03 | 7 | Extracellular structure organization | 0.08 | 3 |
 Response to biotic stimulus | 6.68E−03 | 7 | Regeneration | 0.08 | 3 |
 Antigen processing and presentation of peptide antigen via MHC class I | 0.01 | 3 | Negative regulation of cytokine production | 0.08 | 3 |
 Regulation of multi-organism process | 0.01 | 5 | Lymphocyte-mediated immunity | 0.08 | 3 |
 Response to stimulus | 0.01 | 17 | Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.08 | 3 |
 Regulation of response to external stimulus | 0.01 | 6 | Positive regulation of immune system process | 0.08 | 5 |
 Negative regulation of multicellular organismal process | 0.01 | 7 | Regulation of response to biotic stimulus | 0.08 | 3 |
 Response to virus | 0.01 | 4 | Humoral immune response | 0.08 | 3 |
 Positive regulation of immune response | 0.01 | 5 | Symbiosis, encompassing mutualism through parasitism | 0.08 | 4 |
 Defense response to other organism | 0.02 | 5 | Interspecies interaction between organisms | 0.08 | 4 |
 Regulation of immune system process | 0.02 | 7 | Positive regulation of response to stimulus | 0.08 | 7 |
 Positive regulation of response to external stimulus | 0.02 | 4 | Protein complex binding | 0.08 | 5 |
 Regulation of inflammatory response | 0.02 | 4 | Regulation of localization | 0.09 | 8 |
 Regulation of defense response | 0.03 | 5 | Leukocyte-mediated immunity | 0.09 | 3 |
 Regulation of transport | 0.03 | 8 | Response to external stimulus | 0.09 | 7 |
 Negative regulation of cellular component organization | 0.04 | 5 | Negative regulation of neuron differentiation | 0.09 | 3 |
 Adaptive immune response | 0.04 | 4 | Negative regulation of protein transport | 0.09 | 3 |
 Regulation of lymphocyte mediated immunity | 0.05 | 3 |  |  |  |
B. Significantly enriched GO categories in deprived n-6 PUFA at baseline (non-surgery) vs day 1 LPS-administered mice | |||||
 Innate immune response | 5.95E−08 | 11 | Regulation of defense response | 0.02 | 6 |
 Immune response | 9.19E−08 | 13 | Antigen processing and presentation of peptide antigen via MHC class I | 0.02 | 3 |
 Immune system process | 6.45E−07 | 15 | Lymphocyte-mediated immunity | 0.02 | 4 |
 Defense response | 5.82E−05 | 11 | Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.02 | 4 |
 Type I interferon signaling pathway | 4.14E−04 | 3 | Response to stimulus | 0.02 | 20 |
 Cellular response to type I interferon | 4.14E−04 | 3 | Regulation of immune response | 0.03 | 6 |
 Immune effector process | 9.36E−04 | 7 | Regulation of multi-organism process | 0.03 | 5 |
 Response to type I interferon | 9.36E−04 | 3 | Response to virus | 0.03 | 4 |
 Response to stress | 2.01E−03 | 14 | Response to interferon gamma | 0.03 | 3 |
 Antigen processing and presentation of peptide antigen | 2.01E−03 | 4 | Leukocyte-mediated immunity | 0.03 | 4 |
 Regulation of immune system process | 6.05E−03 | 9 | Positive regulation of defense response | 0.04 | 4 |
 Neuron projection regeneration | 6.05E−03 | 3 | Positive regulation of response to stimulus | 0.04 | 9 |
 Response to external biotic stimulus | 6.05E−03 | 8 | Regulation of transport | 0.04 | 9 |
 Response to other organism | 6.05E−03 | 8 | Defense response to other organism | 0.04 | 5 |
 Response to biotic stimulus | 6.78E−03 | 8 | Regulation of response to stimulus | 0.04 | 12 |
 Glycoprotein binding | 7.16E−03 | 4 | Positive regulation of response to external stimulus | 0.05 | 4 |
 Positive regulation of immune response | 7.40E−03 | 6 | Regulation of inflammatory response | 0.05 | 4 |
 Regulation of response to external stimulus | 7.65E−03 | 7 | Negative regulation of multicellular organismal process | 0.05 | 7 |
 Response to interferon-beta | 7.65E−03 | 3 | G protein-coupled receptor binding | 0.06 | 4 |
 Regulation of lymphocyte migration | 7.65E−03 | 3 | Regulation of cytokine production | 0.06 | 5 |
 Immunoglobulin-mediated immune response | 8.89E−03 | 4 | Extracellular space | 0.07 | 8 |
 B cell-mediated immunity | 9.05E−03 | 4 | Regulation of lymphocyte-mediated immunity | 0.08 | 3 |
 Antigen processing and presentation | 0.01 | 4 | Cytokine-mediated signaling pathway | 0.08 | 4 |
 Regulation of adaptive immune response | 0.01 | 4 | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.08 | 3 |
 Positive regulation of immune system process | 0.01 | 7 | Negative regulation of cellular component organization | 0.08 | 5 |
 Adaptive immune response | 0.01 | 5 | Negative regulation of neuron projection development | 0.09 | 3 |
| Â | Â | Â | Regulation of multicellular organismal process | 0.10 | 10 |