Skip to main content

Table 1 List of significantly enriched Gene Ontology categories in (A) n-6 PUFA adequate and (B) n-6 PUFA deprived at day 1 LPS-administered mice compared to non-surgery mice

From: The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus

GO termBY-corrected p valueNo. of genes driving enrichmentGO termBY-corrected p valueNo. of genes driving enrichment
A. Significantly enriched GO categories in n-6 PUFA adequate at baseline (non-surgery) vs day 1 LPS-administered mice
 Immune response1.18E−0611Regulation of immune response0.055
 Innate immune response1.18E−069Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.053
 Immune system process2.12E−0512Immunoglobulin-mediated immune response0.053
 Cellular response to type I interferon1.90E−043Negative regulation of neuron projection development0.053
 Type I interferon signaling pathway1.90E−043B cell-mediated immunity0.053
 Defense response3.52E−049Regulation of adaptive immune response0.063
 Response to type I interferon3.75E−043Regulation of response to stimulus0.0610
 Antigen processing and presentation of peptide antigen7.9E−044Defense response to virus0.063
 Immune effector process1.84E−036Extracellular space0.067
 Response to stress1.84E−0312Viral process0.064
 Glycoprotein binding2.67E−034Multi-organism cellular process0.064
 Neuron projection regeneration2.67E−033Negative regulation of cell projection organization0.073
 Response to interferon-beta4.35E−033Regulation of immune effector process0.074
 Antigen processing and presentation5.28E−034Regulation of leukocyte mediated immunity0.083
 Response to external biotic stimulus5.46E−037Extracellular matrix organization0.083
 Response to other organism5.46E−037Extracellular structure organization0.083
 Response to biotic stimulus6.68E−037Regeneration0.083
 Antigen processing and presentation of peptide antigen via MHC class I0.013Negative regulation of cytokine production0.083
 Regulation of multi-organism process0.015Lymphocyte-mediated immunity0.083
 Response to stimulus0.0117Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.083
 Regulation of response to external stimulus0.016Positive regulation of immune system process0.085
 Negative regulation of multicellular organismal process0.017Regulation of response to biotic stimulus0.083
 Response to virus0.014Humoral immune response0.083
 Positive regulation of immune response0.015Symbiosis, encompassing mutualism through parasitism0.084
 Defense response to other organism0.025Interspecies interaction between organisms0.084
 Regulation of immune system process0.027Positive regulation of response to stimulus0.087
 Positive regulation of response to external stimulus0.024Protein complex binding0.085
 Regulation of inflammatory response0.024Regulation of localization0.098
 Regulation of defense response0.035Leukocyte-mediated immunity0.093
 Regulation of transport0.038Response to external stimulus0.097
 Negative regulation of cellular component organization0.045Negative regulation of neuron differentiation0.093
 Adaptive immune response0.044Negative regulation of protein transport0.093
 Regulation of lymphocyte mediated immunity0.053   
B. Significantly enriched GO categories in deprived n-6 PUFA at baseline (non-surgery) vs day 1 LPS-administered mice
 Innate immune response5.95E−0811Regulation of defense response0.026
 Immune response9.19E−0813Antigen processing and presentation of peptide antigen via MHC class I0.023
 Immune system process6.45E−0715Lymphocyte-mediated immunity0.024
 Defense response5.82E−0511Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.024
 Type I interferon signaling pathway4.14E−043Response to stimulus0.0220
 Cellular response to type I interferon4.14E−043Regulation of immune response0.036
 Immune effector process9.36E−047Regulation of multi-organism process0.035
 Response to type I interferon9.36E−043Response to virus0.034
 Response to stress2.01E−0314Response to interferon gamma0.033
 Antigen processing and presentation of peptide antigen2.01E−034Leukocyte-mediated immunity0.034
 Regulation of immune system process6.05E−039Positive regulation of defense response0.044
 Neuron projection regeneration6.05E−033Positive regulation of response to stimulus0.049
 Response to external biotic stimulus6.05E−038Regulation of transport0.049
 Response to other organism6.05E−038Defense response to other organism0.045
 Response to biotic stimulus6.78E−038Regulation of response to stimulus0.0412
 Glycoprotein binding7.16E−034Positive regulation of response to external stimulus0.054
 Positive regulation of immune response7.40E−036Regulation of inflammatory response0.054
 Regulation of response to external stimulus7.65E−037Negative regulation of multicellular organismal process0.057
 Response to interferon-beta7.65E−033G protein-coupled receptor binding0.064
 Regulation of lymphocyte migration7.65E−033Regulation of cytokine production0.065
 Immunoglobulin-mediated immune response8.89E−034Extracellular space0.078
 B cell-mediated immunity9.05E−034Regulation of lymphocyte-mediated immunity0.083
 Antigen processing and presentation0.014Cytokine-mediated signaling pathway0.084
 Regulation of adaptive immune response0.014Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.083
 Positive regulation of immune system process0.017Negative regulation of cellular component organization0.085
 Adaptive immune response0.015Negative regulation of neuron projection development0.093
   Regulation of multicellular organismal process0.1010
  1. Based on n = 3 mice per group
  2. BY Benjamini Yekutieli false discovery rate, GO Gene Ontology