Skip to main content
Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

Fig. 9

Illustration of the proposed mechanisms underlying cinobufagin-mediated antinociception through stimulation of spinal microglial IL-10/β-endorphin pathway following α7-nicotinic acetylcholine receptor (α7-nAChR) activation. Cinobufagin and PHA-543613 stimulate mitogen-activated protein kinase (MAPK) activation following agonism of the α7-nAChR and excrete IL-10, which subsequently activates the IL-10 receptor and expresses β-endorphin through an autocrine mechanism. The released β-endorphin passes the microglial neuronal synapse and activates μ-opioid receptor (MOR) in neurons to produce antinociception

Back to article page