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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Fig. 5

Supervised heatmap of 101 CSF EV proteins identified in 20 HIV+ subjects with (n = 10) and without (n = 10) HAND. Proteins identified by ≥ 2 unique peptide counts in 6 or more subjects mapping to immune/inflammatory responses, stress response, myeloid cells, astrocytes, neurons, blood-brain barrier (BBB), and choroid plexus (CP) ontology terms are shown. Columns correspond to individual subjects (font color in black: no HAND; green: ANI; blue: MND; red: HAD; purple: NPI-O) and rows to individual proteins. Color scale (blue-yellow-red) illustrates relative log2 transformed peptide intensities. CSF EV concentrations (particles/ml) and plasma VL were log10 transformed. One HAND subject (ID: 129) had high CSF VL (328 copies/ml) and one non-HAND subject (ID: 072) had high plasma VL (70,953 copies/ml). Triangles at the top illustrate increasing gradient of CSF particle concentrations in subjects with and without HAND. The subject with HIV encephalitis (ID: 151) is highlighted yellow. NCI, neurocognitive impairment

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