Fig. 5From: Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairmentSupervised heatmap of 101 CSF EV proteins identified in 20 HIV+ subjects with (n = 10) and without (n = 10) HAND. Proteins identified by ≥ 2 unique peptide counts in 6 or more subjects mapping to immune/inflammatory responses, stress response, myeloid cells, astrocytes, neurons, blood-brain barrier (BBB), and choroid plexus (CP) ontology terms are shown. Columns correspond to individual subjects (font color in black: no HAND; green: ANI; blue: MND; red: HAD; purple: NPI-O) and rows to individual proteins. Color scale (blue-yellow-red) illustrates relative log2 transformed peptide intensities. CSF EV concentrations (particles/ml) and plasma VL were log10 transformed. One HAND subject (ID: 129) had high CSF VL (328 copies/ml) and one non-HAND subject (ID: 072) had high plasma VL (70,953 copies/ml). Triangles at the top illustrate increasing gradient of CSF particle concentrations in subjects with and without HAND. The subject with HIV encephalitis (ID: 151) is highlighted yellow. NCI, neurocognitive impairmentBack to article page