Fig. 6

Schematic diagram depicting the proposed mechanism involved in HI-induced. The evolution of seizures after HI progresses along the following steps: TRPV1 activated and transported to the astrocytic plasma membrane after HIBD, and it regulated Ca2+ inflow, mediating G-actin polymerized to F-actin, promoting astrocyte migration thus contribute to further spread of proinflammatory factors into the vicinity of neurons to promote the development of seizure. A red question mark indicates problems needed to be solved, and the detailed contents were explained in the discussion section