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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

Fig. 4

Knockdown of APJ abolished the neuroprotective effects of exogenous apelin-13 24 h after SAH. a, b Modified Garcia score and beam balance score. c Representative Western blot images. d Quantitative analyses of APJ, apelin-13, p-AMPK, TXNIP, NLRP3, Bip, IL-1β, TNFα, cleaved caspase-1, and MPO. n = 6 for each group. The bars represent the mean ± SD. *P < 0.05 versus sham, #P < 0.05 versus SAH + vehicle, &P < 0.05 versus SAH + apelin-13. e The level of ROS

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