Fig. 3
From: Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis
Nav1.6 promotes inflammation in EAE mice. Expression in the retina of the markers of inflammation. a Il6 (gene that encodes IL-6) and b Ifng (IFN-γ) is compared between untreated (−EAE) or EAE-induced (+EAE) mice. The eyes of untreated (−EAE) mice are either left uninjected (−AAVCre, open triangles) or injected with AAVCreGFP (+AAVCre, closed triangles). In the EAE-induced mice, a comparison is made between AAVCreGFP-injected (+AAVCre, black dots) and the contralateral eye, which is either left uninjected (blue dots) or injected with a GFP-only control (AAVGFP, green dots). c Analysis of the marker of reactive gliosis Gfap (Glial Fibrillary Acidic Protein). Lines link data points for retinas from the same animal. Data are presented as the mean ± SEM. *P ≤ 0.05, **P ≤ 0.01, paired t test