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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis

Fig. 6

Reduced Nav1.6 levels in optic nerve is associated with decreased demyelination and reduced axonal damage. Electron micrographs of optic nerves from control non-EAE-induced (−EAE) or EAE-induced (+EAE) mice were analyzed. The non-EAE-induced optic nerves are from eyes either left uninjected (−AAVCre, open triangles) or injected with AAVCreGFP (+AAVCre, closed triangles). In the EAE-induced mice, a comparison is made between AAVCreGFP-injected (+AAVCre, black circles) and the contralateral eye, which is either left uninjected (blue dots) or injected with a GFP-only control AAV (green circles). We examined the frequency of a axolytic axons and b demyelinated axons (axons completely devoid of myelin). Based on the g-ratio (see "Materials and methods" section, we also examined the frequency of c optimally myelinated and d demyelinating axons. Data are presented as the mean ± SEM. *P ≤ 0.05; paired t test

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