Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members

Table 3 Results of ANOVA with Single Model comparing means of pre-post cytokine difference for cases versus controls

Gene	Comparison	Mild bTBI Cases^a				Moderate+Severe bTBI Cases
Gene	Comparison	N	mean	(s.e.)	p-value	N	mean	(s.e.)	p-value
βNGF	Case	89	-4.44	19.24		50	-7.39	25.67
βNGF	Control	47	-39.15	26.47	0.29	47	-39.15	26.47	0.39
IL-1ɑ	Case	89	-8.33	5.58		50	-9.92	7.45
IL-1ɑ	Control	47	8.16	7.68	0.08	47	8.16	7.68	0.09
IL-1β	Case	89	-9.81	5.33		50	-7.98	7.11
IL-1β	Control	47	1.56	7.33	0.21	47	1.56	7.33	0.35
IL-4	Case	89	-0.50	1.11		50	-1.60	1.49
IL-4	Control	47	2.51	1.53	0.11	47	2.51	1.53	0.06
IL-6	Case	89	-9.82	11.62		50	-31.60	15.51
IL-6	Control	47	5.13	15.99	0.45	47	5.13	15.99	0.10
IL-8	Case	88	-83.43	21.66		50	-107.67	28.74
IL-8	Control	45	32.86	30.29	<0.01	45	32.86	30.29	<0.01
IL-10	Case	89	-0.10	1.52		50	0.36	2.03
IL-10	Control	47	-1.24	2.09	0.66	47	-1.24	2.09	0.58
IL-13	Case	89	-7.54	10.38		50	-25.03	13.85
IL-13	Control	47	-10.69	14.28	0.86	47	-10.69	14.28	0.47
IL-17	Case	89	14.46	12.88		50	-15.76	17.19
IL-17	Control	47	14.87	17.73	0.99	47	14.87	17.73	0.22
MCP1	Case	89	7.76	10.69		50	-3.95	14.26
MCP1	Control	47	10.72	14.71	0.87	47	10.72	14.71	0.47
MMP3	Case	85	-1,951.88	1,292.01		49	-3,369.24	1,701.68
MMP3	Control	47	1,859.60	1,737.51	0.08	47	1,859.60	1,737.51	0.03
TGFβ1	Case	89	-714.97	1,006.08		50	-1,866.94	1,342.28
TGFβ1	Control	47	-448.46	1,384.46	0.88	47	-448.46	1,384.46	0.46
TNFɑ	Case	89	62.92	109.85		50	-174.31	146.55
TNFɑ	Control	47	8.25	151.16	0.77	47	8.25	151.16	0.39

ISSN: 1742-2094