Fig. 3

Deletion of IL-33 results in sustained retinal inflammation and gliosis post-RD. a Expression levels in normal WT and IL-33^−/− mice. IL-33^−/− retina expressed significantly higher levels of VEGF and C1ra. CCL2, IL-1β, IL-18, GFAP, TGFβ and C1s were at similar levels. b Expression levels at day 7 post-RD. Gene expression levels from day 7 were compared with control retina from the same strain. Upregulated genes to that of RD control were identified in boxes. Expression levels were increased at the similar level in both strains. c Expression levels of retina at day 28 post-RD. Gene expression levels from day 28 were compared with that of control retina from the same strain. Upregulated genes to that of RD control were identified in boxes. Most mRNA levels returned to basal levels at day 28; however, CCL2, IL1β, GFAP and TGFβ in IL-33^−/− retina were higher than in WT. a–c n = 6, Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001