Fig. 2

Elamipretide (SS-31) improved behavioral performance in MWM after exposure to LPS in mice. a Representative trajectories of mice from each experimental group in the probe trial and working trial. During the probe trial, the hidden platform was removed, and during the spatial working memory trial, the hidden platform was changed to the center of the opposite quadrant. The circle represents the previous location of the platform (Probe trial) and the new place of the hidden platform (Working trial). b Each experimental group of mice learned to locate the hidden platform by using the surrounding cues after 5 days of training. In the probe trial, platform-site crossings c, latency to arrive at the primary platform-site d, and the percentage of time that the mouse spent navigating each quadrant e were analyzed. f Latency to get on the new platform during the spatial working memory trial was measured in the indicated group of mice. Data are expressed as the mean ± SE (CON/LPS, 10/15 mice). *P < 0.05, **P < 0.01, ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01 vs. LPS group; &P < 0.05, &&P < 0.01 vs. acquisition day 1. SS-31 elamipretide, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error