Fig. 7

Effects of elamipretide (SS-31) on the BDNF pathway and synaptic plasticity in LPS-treated mice. a, b BDNF/TrkB pathway protein bands on the gel and their relative intensities. c–e The expression levels of BDNF and p-TrkB/TrkB proteins were normalized to that of GAPDH as an internal control. f, g Two kinds of synaptic-structural protein bands on the gel and their relative intensities. h, i The expression levels of SYN and PSD95 proteins were normalized to that of GAPDH as an internal control. Data are expressed as the mean ± SE (n = 6). ***P < 0.001 vs. CON group; #P < 0.05, ##P < 0.01 vs. LPS group. SS-31 elamipretide, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error