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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

Fig. 8

Alteration of dendritic spines on hippocampal neurons visualized with Golgi staining. a, c Golgi staining of dendritic spines in hippocampal dentate granule (DG) neurons and CA1 pyramidal neurons in indicated groups of mice. A magnified view of the green and red boxed areas in a and c is shown on the right side of the group (CON and the LPS groups). Left side of the group: elamipretide and S + L groups. b, d Number of dendritic spines per 10 μm on hippocampal dentate granule (DG) neurons and CA1 pyramidal neurons in indicated groups of mice. Scale bars in a and c, 20 μm; Inset boxes, 10 μm. Data are expressed as the mean ± SE (n = 6). ***P < 0.001 vs. CON group; #P < 0.05, ###P < 0.001 vs. LPS group. SS-31 elamipretide, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error

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