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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions

Fig. 5

Transcriptome analysis of microglial cells purified from the striatum and midbrain. The data were obtained from two independent experiments, the first (Exp 1) with N = 2 mice and the second one (Exp 2) with N = 3 mice. a Venn diagram of the genes differentially expressed between the striatum (Str) and midbrain (Mdb) in the two independent experiments (p < 0.01). The intersection shows the common genes (39) expressed differentially in the 2 experiments. b Enrichment analysis of Gene Ontology biological processes of genes overexpressed in the midbrain using PANTHER. Overrepresentation test and Fisher’s Exact test with a false discovery rate (FDR < 0.01) multiple test correction. c Ingenuity Pathway Analysis of functions regulated by the differentially expressed genes. The intensity of the circle’s color reflects activation or inhibition intensity based on the z-scores, and the nodes represent the genes and their connections to functions

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