Fig. 3

PGRN deficiency impairs neurological recovery, enlarges inflammatory area, and suppresses motor neuron survival after SCI. Assessments of BMS (a), inclined grid walking test (b), and inclined plane test (c) were used to evaluate functional recovery after sham or SCI between WT and Grn^−∕− groups. n = 6 for each group. d H&E staining from longitudinal sections showed the inflammatory area between WT and Grn^−∕− groups. Bar = 200 μm. e Quantification of (d). n = 3 per group. f Nissl staining from transverse sections showed typical views of ventral motor neurons (VMN) between WT and Grn^−∕− groups at different distances from the epicenter of injury. Bar = 50 μm. g Quantification of (f). n = 3 per group. *p < 0.05, ** p < 0.01 WT-SCI vs Grn^−∕−-SCI groups