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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2X4R in spinal cord microglia

Fig. 7

Mechanistic link between P2X4R and anti-allodynic effect. ac Pharmacological interventions of P2X4R. a After 8 h, IVM (positive allosteric modulator of P2X4R subtype) reduces the therapeutic effect of BMSC graft. b TNP-ATP (antagonist of P2X4R subtype) caused the decline of paw withdrawals both in CCD and CCD + BMSC animals in a dose-dependent manner. c Anti-allodynic effect between the two groups with increasing TNP-ATP doses; anti-allodynic effect (percentage) was defined as 100% *(paw withdrawals in PBS control – paw withdrawals after injection)/(paw withdrawals in PBS control). Each time point had a sample size of 6, **p < 0.01, #p < 0.05 compared with PBS control

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