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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

Fig. 2

Decrease of reactive astrogliosis in VPS35CX3CR1 cortex after ischemic stroke. As described in the legend of Fig. 1a, the control (CX3CR1-CreER) and VPS35CX3CR1 mice were injected with tamoxifen at P15, induced photothrombotic stroke at P50, and sacrificed 3 days after the stroke. Their brain sections were subjected to co-immunostaining analyses using indicated antibodies. a, b Representative images. GFAP (glial fibrillary acidic protein), a marker for reactive astrocytes. b Amplified images from the white square marked regions in (a). c, d Quantification analyses (mean ± SEM; n = 4/group; *P < 0.05)

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