Fig. 8
Expression of inflammatory cytokines in VPS35CX3CR1 cortex after ischemic stroke. RT-PCR analysis was performed using total RNA extracted from ischemic brains (of control and VPS35 mutant mice) at 6 h and 1, 3, and 7 days after stroke as described in the legend of Fig. 7. a Relative expression of mRNAs for indicated cytokines at day 3 after stroke. Data are expressed as fold change of mutant vs controls. n = 4 per group. *P < 0.05. b Expression of mRNAs for IL-6, IL-1β, and TNF-α pro-inflammatory cytokines. c Expression of mRNAs for IL-4, IL-10, and TGF-β anti-inflammatory cytokines. Data in b and c are expressed as fold change vs sham-operated controls. n = 4 per group. *P < 0.05