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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease

Fig. 5

Loss of function of sEH increases astrogliosis and the production of cytokines in APP/PS1 Tg mice. a Brain tissue sections from 6-month-old APP/PS1 Tg and APP/PS1 Tg/sEH−∕− mice were immunostained with anti-GFAP (for astrocyte) and FITC-conjugated secondary antibody. Scale bar = 50 μm. b Western blot analysis of protein levels of GFAP and α-tubulin in the brain. cf ELISA of the production of IL-1β, IL-6, IL-4, and IL-10 in brain specimens. g, h The DNA-binding activity of NF-κB and NFAT in brain specimens. Data are mean ± SEM from 8 mice in each group. *P < 0.05 vs. APP/PS1 Tg mice

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