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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

Fig. 7

PFF α-syn mice display no changes in percentage of immune cells in the blood but exhibit decreased numbers of monocytes, neutrophils, and NK cells. Blood PBMCs were prepared from PFF α-syn or monomer α-syn mice at 5 months p.i. (n = 6 per group). a Plots show the numbers of total CD45+ leukocytes, CD19+ B cells, CD4+ T cells, CD8+ T cells, CD11b+ macrophage, Ly6+ neutrophils, and NK1.1+ NK cells. b Plots show the percentages of CD19+ B cells, T cells (CD4+ and CD8+ T cells), CD11b+ macrophage, Ly6+ neutrophils, and NK1.1+ NK cells under the CD45+-gated leukocytes (blue: monomer α-syn; red: PFF α-syn). c Plots show Multiplex proinflammatory cytokine analyses in serum. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s.; not significant, Student’s t test

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