Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease

Table 1 Murine Aim2 protein in neuroinflammation and neurodegeneration

Animal model(s)	Aim2 expression/function	Phenotype/effect	Ref.
ME7 prion, mouse	Aim2 expression upregulated	Neuroinflammation	[12]
Aim2^−/−.B6.Sv129, mice	Aim2 gene deficient	Lower locomotor activity, increased anxious behaviors, reduced fear memory	[46]
Aim2^−/−.B6.Sv129, mice	Aim2 gene deficient	Increased inflammation and adipogenesis; increased expression of the p202 protein	[59]
Traumatic brain injury, mouse	Aim2 inflammasome activation	Pyroptosis in brain microvascular endothelial cells, increased production of neuroinflammatory cytokines	[47]
Stroke, rat	Aim2 inflammasome activation	Production of neuroinflammatory cytokines	[45]
T9 spinal cord contusive injury, rat	Higher expression of Aim2 protein in neurons and microglia	Neuroinflammation	[48]
Aim2^−/−.B6.Sv129; 5XFAD, mice	Aim2 gene deficient	Reduced amyloid-β deposition in brain, increased expression of IL-6 and IL-18 cytokines in the brain	[23]
Aim2^−/−.B6.Sv129; APP/PS1, mice	Aim2 gene deficient	Increased spatial memory, altered structure of dendrites, increased dendritic spine densities	[78]

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