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Table 1 Murine Aim2 protein in neuroinflammation and neurodegeneration

From: Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease

Animal model(s)Aim2 expression/functionPhenotype/effectRef.
ME7 prion, mouseAim2 expression upregulatedNeuroinflammation[12]
Aim2−/−.B6.Sv129, miceAim2 gene deficientLower locomotor activity, increased anxious behaviors, reduced fear memory[46]
Aim2−/−.B6.Sv129, miceAim2 gene deficientIncreased inflammation and adipogenesis; increased expression of the p202 protein[59]
Traumatic brain injury, mouseAim2 inflammasome activationPyroptosis in brain microvascular endothelial cells, increased production of neuroinflammatory cytokines[47]
Stroke, ratAim2 inflammasome activationProduction of neuroinflammatory cytokines[45]
T9 spinal cord contusive injury, ratHigher expression of Aim2 protein in neurons and microgliaNeuroinflammation[48]
Aim2−/−.B6.Sv129; 5XFAD, miceAim2 gene deficientReduced amyloid-β deposition in brain, increased expression of IL-6 and IL-18 cytokines in the brain[23]
Aim2−/−.B6.Sv129; APP/PS1, miceAim2 gene deficientIncreased spatial memory, altered structure of dendrites, increased dendritic spine densities[78]