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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

Fig. 1

LPS, not ISO, induced cognitive impairments and HDAC2 upregulation in mice. a, b The mice in the LPS and ISO + LPS groups but not those in the ISO group showed significantly impaired context-dependent fear memory and tone-dependent fear memory (n = 10). c Impaired object discrimination was observed in the LPS and ISO + LPS groups but not in the ISO group, as revealed by similar percentages for visiting familiar object 1 and novel object 3. d No preference for novel object 3 was observed in the LPS or ISO + LPS group compared with the control group (n = 8). e The expression of HDAC2, but not HDAC3, HDAC4 or HDAC6, was increased in the LPS and LPS + ISO groups but not in the ISO group (n = 4). f The expressions of acetyl-H3, acetyl-H3K9, and acetyl-H3K14 were increased in the LPS and LPS + ISO groups but not in the ISO group (n = 4). Data are presented as the mean ± S.E.M. *P < 0.05; **P < 0.01; and ***P < 0.001

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