Fig. 5

LPS decreased the expression of acetyl-H3, BDNF and c-Fos and suppressed Bdnf and c-fos transcription in hippocampal CaMKII⁺ neurons. a The levels of acetyl-H3 were decreased in the LPS group (n = 4 sections from 4 mice each, scale bar = 100 μm). b LPS exposure significantly decreased the expression of BDNF in CaMKII⁺ neurons in the LPS group (n = 4 sections from 4 mice each, scale bar = 100 μm). c The numbers of c-Fos colocalized with CaMKII neurons significantly decreased in the hippocampal CA1 region in the LPS group (n = 4 sections from 4 mice each, scale bar = 100 μm). d The levels of BDNF and c-Fos were decreased in the LPS group (n = 4). e The mRNA expression of Bdnf and c-fos was decreased in the LPS group (n = 4). f The levels of Bdnf and c-fos, which were bound by acetyl-H3, were decreased in the LPS group. Data are presented as the mean ± S.E.M. ^*P < 0.05; ^**P < 0.01; and ^***P < 0.001