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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

Fig. 6

Suppression of HDAC2 reversed the alterations in BDNF and c-Fos and microglial activation induced by LPS. a–b Representative immunofluorescence images depicting HDAC2 and acetyl-H3 expression in the hippocampal CA1 region in mice treated with ShHdac2-ZsGreen are shown (n = 4, scale bar = 50 μm). c Suppressing HDAC2 expression reversed the LPS-associated decreases in HDAC2 and acetyl-H3 expression in the dorsal hippocampal CA1 region (n = 4 sections from 4 mice each). d–g Suppressing HDAC2 expression reversed LPS-induced alterations in BDNF, c-Fos, acetyl-H3K9, and acetyl-H3K14 expression in the dorsal hippocampal CA1 region (n = 4). h Suppressing HDAC2 expression reversed Iba1 alterations in the LPS group. i The levels of TNF-α, IL-1 and IL-6 in samples from the hippocampus were increased in the LPS + ShHdac2 group compared with the LPS group (n = 4). Data are presented as the mean ± S.E. M. *P < 0.05; **P < 0.01; and ***P < 0.001

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