Fig. 2

Microglia are the principal cell type internalizing Aβ in the absence and presence of IL-1β-mediated neuroinflammation. a Representative flow plots of the gating strategy utilized to analyze viable single cells isolated from mouse hippocampus. b Representative flow plots of the four populations that can be distinguished based on their differential expression of CD45 and CD11b, and representative flow plots of MX04⁺ cells in each population in the hippocampus of APP/PS1 mice transduced with rAAV2-Phe (top) or rAAV2-IL-1β (bottom). c Representative flow plots showing the distribution of MX04⁺ cells in the hippocampus of mice treated with rAAV2-Phe (upper) and rAAV2- IL-1β (lower). d Quantification of results in C for n = 9–10 per group. Data displayed as mean ± SEM, multiple t tests corrected for multiple comparisons using the Holm-Sidak method