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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

Fig. 3

IL-1β does not alter the phagocytic capacity or localization of microglia to Aβ plaques in vivo. a Representative flow plots of hippocampal microglia (CD45loCD11b+) that internalized MX04+-Aβ in the absence and presence of IL-1β overexpression (left), and percentage of MX04+ microglia (right). b Mean fluorescence intensity of MX04 signal in microglia for n = 10–12 per group. Data displayed as mean ± SEM, unpaired t test. c Representative images of Iba1 and 6E10 staining microglia and amyloid beta plaques in the hippocampus of APP/PS1 mice transduced with either rAAV2-Phe or rAAV2-IL-1β. Scale bar = 20 μm. d, e Quantification of the total number of Iba1+6E10+ cells per mm2 (D), % of 6E10+Iba1+/Iba1+ cells (E), and the number of plaque-associated Iba1+ cells that internalize 6E10+-Aβ (right). n = 5 per group. Data displayed as mean ± SEM, unpaired t test

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