Fig. 6

IL-1β, but not Aβ phagocytosis, is associated with large-scale shifts in hippocampal microglia gene expression. a Principal component analysis of 500 top variance genes. b Venn diagram illustrating intersecting differentially expressed genes between each of four tested conditions. c Scatterplot of summarized GO terms obtained using Revigo. Metrics plotted on the graph include relative frequency of the term in the reference gene database, -log10 of p value, and uniqueness of the term relative to other terms in the entire list. A subset of the summarized GO Terms is shown for easier visualization. d Genes of interest associated with IL-1β treatment in MX04⁺ and MX04⁻ microglia. Values plotted indicate log2 fold change from IL-1β-treated relative to Phe-treated in MX04⁺ (top) and MX04⁻ microglia (bottom). Two biological replicates of pooled cells from 6–8 APP/PS1 mouse hippocampi were sequenced for each experimental group