Fig. 4

FGF-induction is specific to CNS cells and depends on a functional HSV-1. a FGF-4 expression of PCCs, astrocytes, and murine mammary gland epithelial cell line (C127i) infected with HSV-1(17⁺)Lox (MOI 10). b FGF-4 expression of mock-infected control primary human keratinocytes compared to HSV-1(17⁺)Lox infected primary human keratinocytes (MOI 10, 6 hpi). Mean ± SEM (n = 3); two-way ANOVA with Holm-Sidak’s multiple comparison test (****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05). c FGF-4 expression in PCCs infected with HSV-1(17⁺)Lox (MOI 10), Theiler’s murine encephalomyelitis virus (TMEV, BeAn, MOI 10) or treated with dithiothreitol (DTT, 1 mM) 6 h after infection or treatment. d Fold change of FGF-4 mRNA in PCCs infected with untreated or UV-inactivated HSV-1(17⁺)Lox. All bars show mean ± SEM (n = 3) with Student’s t test (b), two-way ANOVA (a), and one-way ANOVA (c–d) followed by a Holm-Sidak’s multiple comparison test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)