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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models

Fig. 10

Effect of H89 on PAP-mediated microglial inactivation and CREB phosphorylation in the brains of MPTP-injected mice. a Immunohistochemical staining for Iba-1 and quantification of the number of Iba-1-positive microglia in the substantia nigra of MPTP-injected mice (each group n = 6–7). b The p-CREB levels in microglia were measured by immunofluorescence staining. The white arrows indicate cells positive for both OX42 and p-CREB. *p < 0.05, control vs. MPTP-treated group; #p < 0.05, MPTP vs. MPTP+PAP-treated group; ##p < 0.05, MPTP+PAP vs. MPTP+PAP+H89 group

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Journal of Neuroinflammation

ISSN: 1742-2094