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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis

Fig. 4

Localisation of TNFR expression in the precentral gyrus of SPMS cases. TNFR1 was found expressed by cells with morphology resembling oligodendrocytes (a) as validated by double immunohistochemistry (b) and double immunofluorescence (c, d) with the olig2 oligodendrocyte marker. Furthermore, TNFR1 was found expressed by cells with neuronal morphology (e) as validated by double immunofluorescence (f, g) with NeuN marker of neuronal nuclei. TNFR2 was found expressed by cells with astrocyte morphology (h, j), in particular in the external cortical layer I (h) and II (j). Double immunofluorescence (i, k) with GFAP-specific astrocyte marker confirmed that TNFR2 was mainly expressed by cortical astrocytes. TNFR2 was found expressed also by rare activated microglia/macrophages CD68+ cells (lo) in the external cortical layers of grey matter lesions. Original magnifications: × 100 (l), × 200 (g, h, j); × 400 (af, i, k, mo)

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