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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis

Fig. 6

a Real-time RT-PCR expression of genes related to TNF/TNFR2 pathway overexpressed in the precentral gyrus grey matter lesion (GML) of 10 F− SPMS cases compared with both controls and 10 F+ SPMS cases. For each statistical comparison, the p value, obtained by non-parametric Mann-Whitney test, has been reported (***p < 0.001, **p < 0.01, *p < 0.05). b Schematic diagram of molecular changes involved in TNF/TNFR2 stimulated cell survival signalling significantly upregulated in the F− SPMS cortex (dark green boxes). Light green boxes represent genes that were upregulated in F− SPMS cases but to a lesser extent than in F+ SPMS cases. Changes in both GML and NAGM in each group have been pooled

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