Fig. 3From: Dopamine receptor D3 signalling in astrocytes promotes neuroinflammationDRD3 deficiency results in attenuated microglial activation upon systemic LPS treatment. Wild-type (WT) or DRD3 knockout (DRD3KO) mice received an i.p. injection of LPS (5 mg/kg) or PBS. After 3 h, mice were sacrificed, and microglial activation was analysed by immunohistochemical analysis of Iba1 in the striatum. a Representative overview images at low magnification (× 20) are shown. High magnification (× 100) images are inserted in the bottom-right corner of each overview image. b Quantification of the density of Iba1high cells with ameboid shape. Data from five to six mice per group is shown. Values are the mean ± SEM. *p < 0.05; ***p < 0.001; ****p < 0.0001 by two-way ANOVA followed by Sidak’s post-hoc testBack to article page