Fig. 7

DRD3 deficiency results in altered expression of inflammatory and anti-inflammatory mediators in the midbrain of mice basally and undergoing systemic inflammation induced by LPS. WT (white) or DRD3KO (black) mice were treated with an i.p. injection of LPS (5 mg/kg) or PBS (control). Twenty-four hours later, the midbrain/striatum structures were isolated, disaggregated and the RNA was extracted and analysed by quantitative RT-PCR. Inflammatory (a) and anti-inflammatory mediators were evaluated (b). Gapdh transcript was used as a house keeping for normalization. Data from three to eight mice per group is shown. Values are the mean ± SEM. *p < 0.05 by two-way ANOVA followed by Sidak’s post-hoc test