Skip to main content

Table 2 The analysis of genotype and allele distribution on PD cases and controls

From: Association of LAG3 genetic variation with an increased risk of PD in Chinese female population

SNP

Models

PD

Control

OR

p

rs951818

Dominant ((CC + CA)/AA)

552/77

460/72

1.122 (0.795–1.583)

0.570

Recessive (CC/(CA + AA))

282/347

213/319

1.217 (0.963–1.538)

0.113

Allele (C/A)

834/424

673/391

1.143 (0.963–1.356)

0.137

 Female

Dominant ((CC + CA)/AA)

218/33

154/40

1.716 (1.036–2.843)

0.048

Recessive (CC/(CA + AA))

118/133

59/135

2.030 (1.369–3.010)

0.001

Allele (C/A)

336/166

213/175

1.663 (1.266–2.185)

0.000

 Male

Dominant ((CC + CA)/AA)

334/44

306/32

0.794 (0.491–1.284)

0.412

Recessive (CC/(CA + AA))

164/214

154/184

0.916 (0.682–1.230)

0.610

Allele (C/A)

498/258

460/216

0.906 (0.727–1.130)

0.414

rs1922452

Dominant ((AA+AG)/GG)

555/79

466/59

0.889 (0.621–1.274)

0.583

Recessive (AA/(AG + GG))

282/352

208/317

0.945 (0.703–1.271)

0.108

Allele (A/G)

837/431

674/376

1.083 (0.913–1.286)

0.384

 Female

Dominant ((AA+AG)/GG)

222/34

165/25

0.989 (0.568–1.722)

1

Recessive (AA/(AG + GG))

118/138

58/132

1.975 (1.311–2.888)

0.001

Allele (A/G)

340/172

223/157

1.392 (1.058–1.831)

0.022

 Male

Dominant ((AA+AG)/GG)

333/45

301/34

0.836 (0.521–1.340)

0.531

Recessive (AA/(AG + GG))

164/214

150/185

1.221 (0.965–1.544)

0.766

Allele (A/G)

497/259

451/219

0.932 (0.747–1.162)

0.568

rs870849

Dominant ((CC + CT)/TT)

615/16

513/11

0.824 (0.379–1.792)

0.698

Recessive (CC/(CT + TT))

441/189

373/151

0.945 (0.732–1.218)

0.708

Allele (C/T)

1056/205

886/162

0.942 (0.752–1.179)

0.641

 Female

Dominant ((CC + CT)/TT)

246/4

184/5

1.671 (0.443–6.310)

0.508

Recessive (CC/(CT + TT))

186/64

136/53

1.133 (0.740–1.734)

0.643

Allele (C/T)

432/68

320/58

1.151 (0.788–1.682)

0.527

 Male

Dominant ((CC + CT)/TT)

369/12

329/6

0.561 (0.208–1.511)

0.339

Recessive (CC/(CT + TT))

255/125

237/98

0.844 (0.614–1.160)

0.333

Allele (C/T)

624/137

566/104

0.837 (0.633–1.106)

0.229

  1. PD Parkinson’s disease, OR odds ratio, 95% CI 95% confidence interval. p value obtained by continuity corrected χ2 test. The genotype of rs19922452-AA and rs951818-CC was found to be significantly higher in female PD patients than in controls, respectively (rs951818, OR = 2.03, p = 0.001; rs19922452, OR = 1.975, p = 0.001)