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Fig. 7. | Journal of Neuroinflammation

Fig. 7.

From: The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

Fig. 7.

Exacerbation between G6PD dysfunction and neuroinflammation mediated chronic neurodegeneration. The present study elucidated a pathophysiological role of microglial G6PD in PD neurodegeneration. LPS-induced aberrant upregulation of G6PD promoted cellular oxidative stress and NF-кB activation through increasing NADPH availability to NADPH oxidase. Pharmacological inhibition of G6PD activity or biological knockdown of G6PD attenuated oxidative stress, ameliorated inflammatory response of microglia, and prevented DA neurons from LPS-induced chronic degeneration. G6P, glucose-6-phosphate; G6PD, glucose-6-phosphate dehydrogenase; PPP, pentose phosphate pathway; NADPH, nicotinamideadenine-dinucleotide phosphate; NADP+, oxidized form of NADPH; R5P, ribose-5-phosphate; LPS: Lipopolysaccharide; 6-AN, 6-aminonicotinamide; DHEA, dehydroepiandrosterone; O2−, superoxide; H2O2, hydrogen peroxide; ROS, reactive oxygen species

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