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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke

Fig. 3

TWS119 facilitated post-stroke angiogenesis. a Representative images of coronal sections labeled with CD31 (cerebral microvascular endothelial cells marker). b Area of CD31-positive microvessels were increased in ischemic mice at day 14 and 21 after stroke, and further upregulated by TWS119 treatment at day 21. c Cerebral ischemia enhanced the density of CD31-positive microvessels in peri-infarct cortex at day 14 and 21 after stroke, this change was more significant in TWS119 mice. d Representative images of coronal sections labeled with CD31 or/and BrdU (cell proliferation marker). e TWS119 increased the percentage of CD31+BrdU+ cells in total CD31+ cells at day 14 after stroke. (n = 6 per group, * P < 0.05, ** P < 0.01)

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