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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

Fig. 4

Robust activation of IFN-α-responsive genes in the Npc1−/−/App−/− mouse cerebella. Eighty-four IFN-α-responsive genes are differentially expressed in the Npc1−/−/App−/− cerebella compared with age-matched wild-type littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. A detailed key for IPA molecular shape, color, and interaction is provided in Fig. 2

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