Fig. 6
From: Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C
Infiltration of CD3+ T cells in cerebellum. Immunohistochemical staining reveals the presence of CD3+ cells in the molecular layer of the cerebellum of App−/−/Npc1−/− mice at terminal disease stage, but not in any other genotypes. Shown for comparison as a positive control is CD3 staining of T cells in mice following a traumatic brain injury protocol as described in the Methods section. a–c Npc1+/+/App+/+ mice at 12 weeks of age. d–f Npc1−/−/App+/+ mice at terminal disease stage. g–i Npc1+/+/App−/− mice at 12 weeks of age. j–l App−/−/Npc1−/− mice at terminal disease stage. g: granular layer of the cerebellum; m: molecular layer of the cerebellum. m–o Traumatic brain injury positive control. Shown is the lesion area, as described in the Methods section. White asterisks show CD3+ cells and white arrows show areas of stained patterns artifactual in nature, as they appear in all genotypes and all ages tested