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Table 1 Differentially expressed genes identified in each genotype by genome-wide transcriptome analysis. TR number of transcript-reads by microarray, aFC absolute fold-change, DEG differentially expressed gene (mapped ID + statistically significant by FC and p cutoffs)

From: Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

 Npc1+/+/App−/−Npc1−/−/App+/+Npc1−/−/App−/−
TR (aFC > 1.5)626939677132
TR (p < 0.05)15346843359
DEG (FC + p)8914311973
DEG (up)4182521265
DEG (down)473179708