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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 1

Effects of URB, autophagy inhibitor 3-MA and lysosome inhibitor CQ on CCH-induced up-regulation of proinflammatory cytokines. a The protein levels of IL-1β in the hippocampus. b The protein levels of TNF-α in the hippocampus. c Representative western blot and relative optical density analysis of COX-2 and β-actin in the hippocampus. d Representative western blot and relative optical density analysis of iNOS and β-actin in the hippocampus. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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