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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 3

p62 may not be necessary for removing NLRP3 inflammasome in the process of autophagy after URB treatment. a Representative immunofluorescence staining for NLRP3 and p62 in the hippocampal CA1 region. (scale bars = 20 μm). Green puncta: NLRP3 inflammasome; red puncta: p62; yellow puncta: p62/NLRP3 overlap. b Relative level of p62 (ratio of the sham group). The p62-positive puncta in the sham group are set to 1. c Relative level of NLRP3 (ratio of the sham group). The NLRP3-positive inflammasome in the sham group is set to 1. d Relative level of p62/NLRP3 overlap (p62/NLRP3 overlap/mm2). Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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