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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 4

The activation of CCH-induced NLRP3 inflammasome may not be restrained by controlling the autophagosome formation stage after URB treatment. a Representative immunofluorescence staining for NLRP3 and LC3 in the hippocampal CA1 region. (scale bars = 20 μm). Green puncta: NLRP3 inflammasome; red puncta: LC3-positive autophagosome; yellow puncta: LC3/NLRP3 overlap. b Relative level of LC3 (ratio of the sham group). The LC3-positive autophagosome in the sham group is set to 1. c Relative level of NLRP3 (ratio of the sham group). The NLRP3-positive inflammasome in the sham group is set to 1. d Relative level of LC3/NLRP3 overlap (ratio of the sham group). The LC3/NLRP3 overlap in the sham group is set to 1. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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Journal of Neuroinflammation

ISSN: 1742-2094