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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Fig. 8

The clearance of CCH-induced damaged mitochondria may be enhanced by restoring the lysosomal function after URB treatment. a Representative immunofluorescence staining for LAMP1 and TOM-20 in the hippocampal CA1 region. (scale bars = 20 μm). Green puncta: TOM-20-positive mitochondria; red puncta: LAMP1-positive lysosome; yellow puncta: LAMP1/TOM-20 overlap. b Relative level of LAMP1 (ratio of the sham group). The LAMP1-positive lysosome in the sham group is set to 1. c Relative level of TOM-20 (ratio of the sham group). The TOM-20-positive mitochondria in the sham group are set to 1. d Relative level of LAMP1/TOM-20 overlap (ratio of the sham group). The LAMP1/TOM-20 overlap in the sham group is set to 1. Data are expressed as mean ± SEM (n = 5). *P < 0.05 versus sham group. **P < 0.05 versus BCCAo group. #P < 0.05 versus BCCAo+URB group

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Journal of Neuroinflammation

ISSN: 1742-2094