Fig. 11From: Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activityMechanism of action of PEA in RBL-2H3 cells as suggested by the present study. PEA, by stimulating the activity of DAGL-β, increases the endogenous levels of 2-AG, which, by directly activating the CB2 receptor, blocks histamine release and mast cell degranulation induced by substance PBack to article page